research magnet Research Magnet news Medical News

View research about

Essential mixed cryoglobulinemia Dentist Paediatric Cardiology Autoimmune dysautonomia Pain Medicine Fitness Inclusion body myositis (IBM) Juvenile myositis (JM) Pathology Sarcoma Colorectal Cancer Alopecia areata Pemphigus Vascular Surgery Cleft Lip Gall Bladder Cancer Dementia Dermatomyositis Progesterone dermatitis Transverse myelitis Sports Medicine Medical Charity ADHD Foot & Ankle Orthopaedics Cosmetic Surgery Interstitial cystitis (IC) Brain Tumor Primary Biliary Cholangitis Endocrinology Subacute bacterial endocarditis (SBE) Leukodystrophy Procedural Dermatology Molecular Genetic Pathology Autoimmune retinopathy Heart Failure Coronary Artery Disease Narcolepsy Peripheral neuropathy Malignant Hypertension Implantology Angina Paediatric Dentistry Transplant Heamatology Pure red cell aplasia (PRCA) Castleman disease (CD) Nephrology Autoimmune encephalomyelitis Chronic Lymphocytic Leukaemia Orthopaedic Surgery Bile Duct Cancer Undifferentiated connective tissue disease (UCTD) Dressler’s syndrome Dermatology Hyperlipidaemia Cold agglutinin disease Musculoskeletal Oncology Cardiothoracic Surgery Doctor Optic neuritis Epilepsy Parkinson’s Disease Surgical Oncology Ocular cicatricial pemphigoid Overactive Bladder Devic’s disease (neuromyelitis optica) Anti-GBM/Anti-TBM nephritis Autoimmune myocarditis Polymyalgia rheumatica Lower GI Guillain Barre Syndrome Temporal arteritis/Giant cell arteritis Low Back Pain Lung Cancer Hand Surgery Paediatric Surgery Hypertriglyceridemia Perivenous encephalomyelitis Neuroendocrine Tumors Antiphospholipid syndrome Spinal Cord Injury Upper GI Biochemical Genetics Microbiology Reflex sympathetic dystrophy COVID-19 Henoch-Schonlein purpura (HSP) Chronic inflammatory demyelinating polyneuropathy (CIDP) Polyglandular syndromes type I, II, III Paediatric ICU Maternal & Fetal Medicine Cancer Hypogammalglobulinemia Endovascular surgery Discoid lupus Hip & Knee Osteoarthritis Asthma Rheumatic fever Parry Romberg syndrome Pediatrics Obesity & Bariatrics Pancreatic Cancer Prediabetes Syncope & Collapse Microscopic polyangiitis (MPA) Hospice And Palliative Medicine Urology Behcet’s disease General Medicine / Internal Medicine Granulomatosis with Polyangiitis Spina Bifida Thoracic Surgery Neonatal & Perinatal Medicine Bladder Cancer Hepatology Ophthalmology Podiatrist Traumatic Brain Injury Coronavirus Transplant Hepatology Clinical Pharmacology Autoimmune orchitis Specialist In Training Chronic recurrent multifocal osteomyelitis (CRMO) Occupational & Environmental Medicine Liver Cancer Vaginal Cancer Clinic Ankylosing spondylitis Neurosurgery Schmidt syndrome General Surgery Hidradenitis Suppurativa (HS) (Acne Inversa) Evans syndrome Obstetrics And Gynecology Chiropractor Dermatological Immunology Pulmonology Stem Cell Research Pyoderma gangrenosum Psychiatry Immunology & Allergy Amyloidosis Critical Care Ulcerative colitis (UC) Retroperitoneal fibrosis Autoimmune inner ear disease (AIED) Peripheral Vascular Disease Depression Undersea & Hyperbaric Medicine Mona Vale ED Acute Myeloid Leukaemia Thyroid eye disease (TED) Herpes gestationis or pemphigoid gestationis (PG) Psoriasis Lupus Macular Degeneration Pernicious anemia (PA) Head & Neck Surgery Geriatric Psychiatry Cardiology Pharmacy Reactive Arthritis Melanoma Psychosomatic Medicine Linear IgA disease (LAD) Chronic Kidney Disease Palliative Medicine Bullous pemphigoid Clinical Cytogenetics Mitochondrial Myopathies Chronic Ischaemic Heart Disease Audiologist Congenital heart block Tropical Medicine Adolescent Medicine Otology Neurotology Dermatitis herpetiformis Juvenile diabetes (Type 1 diabetes) Muscular Dystrophy Clinical Paediatric Genetics Moya Moya Disease Prostate Cancer Myelin Oligodendrocyte Glycoprotein Antibody Disorder Churg-Strauss Syndrome Restless legs syndrome (RLS) ENT Paediatric Physician Pregnancy Reproductive Endocrinology & Infertility Vulval Cancer Giant cell myocarditis Alzheimers Autoimmune oophoritis Sympathetic ophthalmia (SO) Benign Hypertension Aerospace Medicine Speech Pathologist Medical Administration Palindromic rheumatism (PR) Atrial Fibrillation Transplant Nuclear Medicine Women's Health Breast Fibromyalgia Meningitis CREST syndrome Takayasu’s arteritis Osteopathy Relapsing polychondritis Kawasaki disease Ligneous conjunctivitis Huntingtons Disease Goodpasture’s syndrome COPD Bowel Cancer Skin Cancer Mooren’s ulcer Pars planitis (peripheral uveitis) Inflammatory Arthritis Primary sclerosing cholangitis Haematology Rural & Remote Agammaglobulinemia Organ Donation Raynaud’s phenomenon Addiction Psychiatry Histopathology Vogt-Koyanagi-Harada Disease Hashimoto’s thyroiditis Radiation Oncology Paediatric Respiratory Baló disease Craniofacial Surgery Anal Cancer Medical Organisation Chiropractice Infectious Disease Clinical Researcher Laboratory Immunology Sexual Health Medicine Addison’s disease Achalasia Vitiligo Scleroderma Eosinophilic esophagitis (EoE) Parsonage-Turner syndrome Rare Disease Craniofacial Microsomia Immune thrombocytopenic purpura (ITP) Lambert-Eaton syndrome Rare Diseases Coeliac disease Neurodevelopmental Disabilities Sleep Medicine Lichen planus Mircobiology Diabetes & Metabolism Burns Cystic Fibrosis Optometry Spinal Surgery Clinical Cardiac Electrophysiology Complementary Medicine Delirium Physiotherapy Emergency Medicine Brain Injury Medicine Hospital Geriatric Medicine Polymyositis Insulin Resistance Fibrosing alveolitis Anesthesiology Neuro Ophthalmology Axonal & neuronal neuropathy (AMAN) MedicalDirector software Testicular Cancer Schizophrenia Mucha-Habermann disease Rheumatology Womb Cancer Clinical Genetics Adult Reconstructive Orthopaedics Gynecologic Oncology Neonatal Lupus Chronic Myeloid Leukaemia Gynaecology Pediatric Allergy & Immunology Paediatric Emergency Medicine Uveitis & Ocular Immunology Hemolytic anemia Internal Medicine Oesophaegal Cancer Forensic Psychiatry Physiotherapist Paediatric Orthopaedics Oncology Cerebral Atherosclerosis Myeloma cleft palate Provider Postpericardiotomy syndrome Penile Cancer Neurology Queer Health Occupational Therapy Cardiothoracic Intensive Care Chinese Medical Practitioner Cerebrovascular & Skull Base Surgery Disaster Medicine Chagas disease Intensive Care Medicine International Health Sleep Apnoea Glomerulonephritis Psychologist Nutrition Graves’ disease TIA Interventional Radiology Acute Lymphoblastic Leukaemia Thyroid Cancer Dietician Crohn’s disease Sports & Exercise Medicine Scleritis Advanced Heart Failure & Transplant Cardiology Orthodontics Adult Still's disease Dentistry Myelodysplasia Cicatricial pemphigoid Paramedicine Cosmetic Medicine Lichen sclerosus Radiology Multiple Sclerosis Neuro Oncology Child And Adolescent Psychiatry Geriatric Wellness Polyarteritis nodosa Phonetics Hypercholesterolaemia Neurodegenerative Disorders Myocardial infarction Kidney Cancer Stiff person syndrome (SPS) Cataracts Neuro Intensive Care Susac’s syndrome Neuromuscular Medicine Leukocytoclastic vasculitis POEMS syndrome Eosinophilic fasciitis Cogan’s syndrome Thrombocytopenic purpura (TTP) Meniere’s disease Ophthalmic Pathology Endovascular Surgical Neuroradiology Optometrist Audiology Sperm & testicular autoimmunity Carotid Artery occlusion Adult Cardiothoracic Anesthesiology Gastroenterology Giant cell arteritis (temporal arteritis) Simulation Medicine Sjögren’s syndrome Stroke Multifocal Motor Neuropathy (MMN) Autoimmune urticaria HIV / AIDS Female Pelvic Medicine & Reconstructive Surgery Respiratory Medicine IgG4-related sclerosing disease Tolosa-Hunt syndrome (THS) Nurse Juvenile arthritis Celiac disease Diabetes Mellitus Mouth, Head and Neck Cancer Pharmacist Sarcoidosis Autoimmune pancreatitis Oral Health Dermatopathology Laryngeal Cancer Lyme disease chronic Autoimmune hepatitis Paraneoplastic cerebellar degeneration (PCD) Interventional Cardiology Technology Podiatry Endoscopy Stomach Cancer Patient Paroxysmal nocturnal hemoglobinuria (PNH) Psychology Benign mucosal pemphigoid Psoriatic arthritis Endometriosis Obstetric Anesthesiology Healthcare Otolaryngology Bariatric Surgery Coxsackie myocarditis Breast Cancer Nuclear Radiology Applied Dermatology Metabolic Syndrome Cervical Cancer Uterine Cancer Eye Cancer Diagnostic Laboratory Immunology Transplant Pulmonology IgA Nephropathy Public Health Rehabilitation Medicine Erythema nodosum Mesothelioma Robotic Surgery Inflammatory Bowel Disease Clinical Immunology General Practice (Family Medicine) Toxicology ATSI Health Practitioner Non Hodgkin Lymphoma Transplant Nephrology Wheel Travel Medicine Neutropenia Public Health Medicine Musculoskeletal Radiology Retrieval Medicine Blood Cancer Ovarian Cancer Addiction Medicine Plastic Surgery Conference Organiser Osteopath Oral & Maxillofacial Surgery Motor Neuron Disease Occupational Therapist Trauma Cerebral Palsy Autoimmune angioedema

The latest medical research on Transplant

The research magnet gathers the latest research from around the web, based on your specialty area. Below you will find a sample of some of the most recent articles from reputable medical journals about transplant gathered by our medical AI research bot.

The selection below is filtered by medical specialty. Registered users get access to the Plexa Intelligent Filtering System that personalises your dashboard to display only content that is relevant to you.

Want more personalised results?

Request Access

Direct Oral Anticoagulation in Lung Transplant Recipients.

Exp Clin Transplant

Presently, the management of direct oral anticoagulants lacks specific guidelines for patients before and after transplant, particularly for lung transplant recipients. We aimed to consolidate the existing literature on direct oral anticoagulants and explore their implications in lung transplant recipients.

We conducted a comprehensive search in PubMed and Google Scholar databases for studies published between January 2000 and December 2022, using specific search terms. We only included studies involving lung transplant recipients and focusing on direct oral anticoagulants.

Five relevant publications were identified, providing varied insights. None of the studies specifically addressed bleeding complications associated with direct oral anticoagulants in lung transplant recipients. Limited details were available on the type of solid-organ transplant or the specific direct oral anticoagulant used in these studies.

Varied bleeding complications associated with direct oral anticoagulants in lung transplant recipients were reported, but studies lacked specificity on transplant type and direct oral anticoagulant variations. Notably, the incidence of venous thrombotic embolism in lung transplant recipients was comparatively higher than in other solid-organ transplant recipients, potentially linked to factors such as corticosteroid therapy, calcineurin inhibitors, and cytomegalovirus infections. Our synthesis on findings of use of direct oral anticoagulant in lung transplant recipients emphasized challenges of managing these medications in urgent transplant situations. Recommendations from experts suggested caution in initiation of direct oral anticoagulants posttransplant until stability in renal and hepatic function is achieved. The limited evidence on safety of direct oral anticoagulants in lung transplant recipients underscores the need for further research and guidance in this specific patient population.

Abdominal Transplant Surgeons: The Lack of Female Surgeons and People From Underrepresented Racial and Ethnic Minority Groups in Academic and Clinical Leadership.

Exp Clin Transplant

The demographic disparities among surgeons in academic leadership positions is well documented. We aimed to characterize the present demographic details of abdominal transplant surgeons who have achieved academic and clinical leadership positions.

We reviewed the 2022-2023 American Society of Transplant Surgeons membership registry to identify 1007 active abdominal transplant surgeons. Demographic details (academic and clinical titles) were collected and analyzed using the chi-square test, the Fisher exact test, and t tests. Multinomial logistic regressions were conducted.

Female surgeons (P < .001) and surgeons from racial-ethnic minorities (P = .027) were more likely to be assistants or associates rather than full professors. White male surgeons were more likely to be full professors than were White female (P < .001), Asian female (P = .008), and Asian male surgeons (P = .005). There were no Black female surgeons who were full professors. The frequency of full professorship increased with surgeon age (P < .001). Male surgeons were more likely to hold no academic titles (P < .001). Female surgeons were less likely to be chief of transplant(P = .025), chief of livertransplant (P = .001), chief of pancreas transplant (P = .037), or chair of surgery (P = .087, significance at 10%). Chief of kidney transplant was the most common clinical position held by a surgeon from a racial or ethnic minority group. Female surgeons were more likely to hold no clinical titles (P = .001).

The underrepresentation of women and people from racial and ethnic minority groups in academic and clinical leadership positions in the field of abdominal transplant surgery remains evident. White male physicians are more likely to obtain full professorship, and they comprise most of the clinical leadership positions overall. A continued push for representative leadership is needed.

BK Viremia and Viruria Does Not Depend on the Type of Double-J Stent Used During Kidney Transplantation.

Exp Clin Transplant

BK virus is a major cause of chronic renal allograft failure.Transplant ureteral stent use has been reported as a risk factorfor BK virus infection. Recently, the use of a new type of ureteral stent (Magnetic Black Star) was reported in kidney transplant recipients. The aim ofthis preliminary report was to compare BK virus viremia and viruria occurrence depending on the type of double-J stent (standard versus Magnetic Black Star).

We included all kidney transplants performed in our center from January to December 2022. Each case had double-J stent placement. Indwelling stents were either a 6- or 7-Fr standard double-J stent or a 6-Fr Magnetic Black Star double-J stent. The type of double-J stent was chosen according to the surgeon's preference. A standard BK virus screening protocol was followed during the study period, which consisted of routine polymerase chain reaction examination of plasma and urine samples during monthly follow-ups.

We assessed 120 patients without missing data: 92 patients received standard double-J stents and 28 patients received Magnetic Black Star stents. Patients were mostly male in the standard group (70.7%) versus the Magnetic Black Star group (42.9%) (P = .01). ABO- and HLA-incompatible transplant rates were similar in both groups. BK viremia occurrence and BK viruria occurrence were similar between groups at 1 month, 3 months, and 6 months.

This preliminary study showed no differences concerning BKvirus infection depending on the type of double-J stents used during kidney transplant.

Effects of Antithymocyte Globulin, Basiliximab, and Induction-Free Treatment in Living Donor Kidney Transplant Recipients on Tacrolimus-Based Immunosuppression.

Exp Clin Transplant

Induction treatment in renal transplant is associated with better graft survival. However, intensified immunosuppression is known to cause unwanted side effects such as infection and malignancy. Furthermore, the effects of the routine use of immunosuppressants in low-risk kidney transplant recipients are still not clear. In this study, we assessed the first-year safety and efficacy of induction treatment.

We examined first living donor kidney transplant patients who were on tacrolimus based immunosuppression therapy. We formed 3 groups according to the induction status: antithymocyte globulin induction, basiliximab induction, and no induction. We collected outcome data on delayed graft function, graft loss, creatinine levels, estimated glomerular filtration rates, acute rejection episodes, hospitalization episodes, and infection episodes, including cytomegalovirus infection and bacterial infections.

We examined a total of 126 patients (age 35 ± 12 years; 65% male). Of them, 25 received antithymocyte globulin, 52 received basiliximab, and 49 did notreceive any induction treatment. We did not observe any statistically significant difference among the 3 groups in terms of acute rejection episodes, delayed graft function, and first-year graft loss. The estimated glomerular filtration rates were similar among the groups. Overall bacterial infectious complications and cytomegalovirus infection showed similar prevalence among all groups. Hospitalization was less common in the induction-free group.

In low-risk patients, induction-free regimens could be associated with a better safety profile without compromising graft survival. Therefore, induction treatment may be disregarded in first living donor transplant patients who receive tacrolimusbased triple immunosuppression treatment.

Diagnosis and Management of Ureteropelvic Obstruction in Kidney Transplant Recipients and Outcomes of Foley Y-V Pyeloplasty.

Exp Clin Transplant

To evaluate the etiology and diagnostic tools for ureteropelvic obstruction in kidney transplant recipients, we investigated the short-term and long-term outcomes of Foley Y-V pyeloplasty.

We retrospectively reviewed 10 patients who underwent kidney transplant followed by additional interventions to treat obstructive ureteral pathologies between 2016 and 2020. We enrolled 4 patients who had received intervention to treat ureteropelvic obstruction. For these 4 patients, serum creatinine and estimated glomerular filtration rate levels were recorded at baseline, during the symptomatic period, and long-term. In this single center study, we investigated diagnostic tools and management strategies for ureteropelvic obstruction and assessed performance of Foley Y-V nondismembered pyeloplasty in kidney transplant recipients.

Among 4 patients, graft function (assessed by serum creatinine and estimated glomerular filtration rate) worsened significantly (P = .03) in the symptomatic period of ureteropelvic obstruction in all patients; however, graft function levels improved rapidly to levels similar to baseline (P = .07) after Y-V pyeloplasty. In addition, no statistically significant difference was detected between baseline and longterm graft functions afterY-V pyeloplasty in follow-up (P = .28).

Diagnosis and management of ureteropelvic obstruction in kidney transplant recipients are challenging due to rarity and lack of an ideal management algorithm.There is no specific diagnostic tool to discriminate this pathology from other ureteral pathologies; therefore, a regimen of conventional imaging modalities and diuretic renogram combined with endoscopic evaluation is more reliable. Moreover, nondismembered Foley Y-V pyeloplasty is effective and safe for graft function in the short-term and long-term.

Effect of Splenectomy on Coagulation and Platelet Function in Adult Liver Transplant Recipients Assessed With Rotational Thromboelastometry and Standard Coagulation Tests.

Exp Clin Transplant

Splenectomy during liver transplant can affect platelet function. In this study, our primary aim was to assess the perioperative platelet function by rotational thromboelastometry and the effects of splenectomy on platelet function.

We studied 40 consecutive liver transplant recipients with end-stage liver disease (50% as a result of hepatitis C). Patients with splenectomy were compared with patients without splenectomy (n = 20/group). Three platelet function parameters by rotational thromboelastometry were studied: platelet activation with arachidonic acid, platelet activation with adenosine diphosphate, and platelet activation with thrombin receptor-activating peptide 6. Patients were monitored perioperatively and until postoperative day 21. Heparin was infused for 2 days postoperatively (60-180 U/kg/day), followed by administration of subcutaneous low-molecular-weight heparin (40 mg/24 h) on postoperative days 2 and 3 and oral acetylsalicylic acid when platelet count was >50 × 103/μL.

Liver disease contributed to low perioperative platelet count and function. Patients showed significant improvement by postoperative day 14 and day 21, particularly after splenectomy. Platelet count was significantly correlated with the 3 platelet function parameters by rotational thromboelastometry (P < .001). Acetyl salicylic acid was required earlier (postoperative day 3) for patients with splenectomy (8/20) but only affected the platelet function represented by platelet activation with arachidonic acid, whereas other platelet activation pathways were less affected. Patients received no transfusions of platelet units.

End-stage liver disease significantly contributed to low platelet function and counts before transplant. Two weeks were required for recovery of patients posttransplant, with further enhancement by splenectomy. Some recipients showed recovery that exceeded the normal reference range, which warranted monitoring. Acetyl salicylic acid only affected 1 platelet activation receptor.

Bronchiectasis After Solid-Organ Transplant: A Retrospective Single Center Study.

Exp Clin Transplant

Bronchiectasis is characterized by abnormal, persistent, and irreversible enlargement of the bronchi. Many etiological factors have been described, but there are limited data on the development of bronchiectasis after organ transplantation. Our study is the first to study evaluate the frequency of bronchiectasis in heart and liver transplants as well as kidney transplants. Our aim is to analyze the frequency of bronchiectasis development after solid-organ transplant and the characteristics of the cases and to evaluate potential relationships.

We retrospectively analyzed data of patients who underwent solid-organ transplant at the Başkent University Faculty of Medicine Hospital through the hospital electronic information system. Demographic, clinical, and laboratory data and thoracic computed tomography scans were evaluated.

The study included 468 patients (151 females/317 males). Kidney transplant was performed in 61.5% (n = 207), heart transplant in 20.3% (n = 95), and liver transplant in 18.2% (n = 85) of patients. Development of bronchiectasis was detected in only 13 patients (2.7%). We determined a 13.64-fold risk of developing bronchiectasis in patients with chronic obstructive pulmonary disease and 10.08-fold risk in patients with pneumonia by multivariate regression analyzes, in which all possible risk factors for the development of bronchiectasis after transplant were evaluated.

The pathophysiology of transplantassociated bronchiectasis has not yet been clarified. Underlying diseases, recurrent pulmonary infections, and potential effects from immunosuppressive drugs may contribute to the pathogenesis of bronchiectasis. Further prospective studies are needed to include long-term health outcomes in transplant patients with and without bronchiectasis.

Carbapenem-Resistant Pseudomonas aeruginosa Infection and Mixed Infections Are Risk Factors for Poor Outcome After Lung Transplant.

Exp Clin Transplant

In this study, we analyzed the effects of carbapenem-resistant Pseudomonas aeruginosa infection and mixed infection on the perioperative prognosis of lung transplant recipients and studied statistics on antibiotic resistance in P aeruginosa.

This was a retrospective casecontrol study. We collected data on lung transplant recipients with combined lower respiratory tract P aeruginosa infection within 48 hours after lung transplant at the China-Japan Friendship Hospital from August 2018 to April 2022. We grouped recipients according to P aeruginosa resistance to carbapenem antibiotics and summarized the clinical characteristics of carbapenem-resistant P aeruginosa infection. We analyzed the effects of carbapenemresistant P aeruginosa infection and mixed infections on all-cause mortality 30 days after lung transplant by Cox regression. We used the Kaplan-Meier method to plot survival curves.

Patients in the carbapenem-resistant P aeruginosa group had a higher all-cause mortality rate than those in the carbapenem-sensitive P aeruginosa group at both 7 days (6 patients [22.3%] vs 2 patients [4.5%]; P = .022) and 30 days (12 patients [44.4%] vs 7 patients [15.9%]; P = .003) after lung transplant. In multivariate analysis, both carbapenemresistant P aeruginosa infection and P aeruginosa combined with bacterial infection were independent risk factors for death 30 days after transplant in lung transplant recipients (P < .05). In subgroup analysis, carbapenem-resistant P aeruginosa combined with bacterial infection increased the risk of death 30 days after transplant in lung transplant recipients compared with carbapenem-sensitive P aeruginosa combined with bacterial infection (12 patients [60%] vs 6 patients [19.4%]; P < .001).

Combined lower respiratory tract carbapenem-resistant P aeruginosa infection and P aeruginosa combined with bacterial infection early after lung transplant increased the risk of 30-day mortality after lung transplant.

Acute Airway Obstruction: An Unusual Presentation of Posttransplant Lymphoproliferative Disorder in a Renal Transplant Recipient.

Exp Clin Transplant

Posttransplant lymphoproliferative disorder is a life-threatening complication after solid-organ transplants. In adults, recipients of heart transp...

Hepaticoduodenostomy for Recurrent Biliary Anastomotic Stricture after Liver Transplant.

Exp Clin Transplant

Biliary strictures afterlivertransplant are amenable to endoscopic dilatation or percutaneous dilatation and stenting in most cases. In rare cases,...

Mucormycosis in Liver Allograft Following Transplant for Secondary Biliary Cirrhosis.

Exp Clin Transplant

Mucormycosis, a group of opportunistic mycoses caused by Mucorales, present a significant threat to immunocompromised patients. In this report, we ...

Tigecycline-Associated Hepatic Steatosis After Liver Transplant: A Case Report.

Exp Clin Transplant

Tigecycline is a parenteral glycycline antibiotic that is used to treat severe infections caused by susceptible organisms, butitis also associated ...