The latest medical research on Clinical Genetics

The research magnet gathers the latest research from around the web, based on your specialty area. Below you will find a sample of some of the most recent articles from reputable medical journals about clinical genetics gathered by our medical AI research bot.

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Activation of toll-like receptor signaling in endothelial progenitor cells dictates angiogenic potential: from hypothesis to actual state.

Cell and Tissue Research

Human endothelial progenitor cells (EPCs) were isolated from cord blood samples and enriched by magnetic activated cell sorting method based on the...

From immune to olfactory expression: neofunctionalization of formyl peptide receptors.

Cell and Tissue Research

Variations in gene expression patterns represent a powerful source of evolutionary innovation. In a rodent living about 70 million years ago, a gen...

The neuroethology of olfactory sex communication in the honeybee Apis mellifera L.

Cell and Tissue Research

The honeybee Apis mellifera L. is a crucial pollinator as well as a prominent scientific model organism, in particular for the neurobiological stud...

Fibronectin-integrin signaling regulates PLVAP localization at endothelial fenestrae by microtubule stabilization.

Cell and Tissue Research

Endothelial fenestrae are the transcellular pores existing on the capillary walls which are organized in clusters referred to as sieve plates. They...

miR-146a-3p suppressed the differentiation of hAMSCs into Schwann cells via inhibiting the expression of ERBB2.

Cell and Tissue Research

Human amniotic mesenchymal stem cells (hAMSCs) can be differentiated into Schwann-cell-like cells (SCLCs) in vitro. However, the underlying mechani...

The functional relevance of olfactory marker protein in the vertebrate olfactory system: a never-ending story.

Cell and Tissue Research

Olfactory marker protein (OMP) was first described as a protein expressed in olfactory receptor neurons (ORNs) in the nasal cavity. In particular, ...

The cyclic AMP signaling pathway in the rodent main olfactory system.

Cell and Tissue Research

Odor perception begins with the detection of odorant molecules by the main olfactory epithelium located in the nasal cavity. Odorant molecules bind...

MiR-150-5p regulate T cell activation in severe aplastic anemia by targeting Bach2.

Cell and Tissue Research

MiR-150-5p is an immune-related miRNA and elevated in the plasma of patients with aplastic anemia (AA), but its role in T cell activation in patien...

LncRNA MCM3AP-AS1 inhibits the progression of colorectal cancer via the miR-19a-3p/FOXF2 axis.

J Gene Med

Long non-coding RNA MCM3AP antisense RNA 1 (lncRNA MCM3AP-AS1) has a regulatory role in the development of diverse malignancies, while its role and mechanism in colorectal cancer (CRC) is not yet clear.

The relative expressions of MCM3AP-AS1, miR-19a-3p, and forkhead box F2 (FOXF2) mRNA in 53 cases of CRC and its adjacent normal tissues, human normal colonic mucosal cells (FHC cells) and CRC cell lines were examined by qRT-PCR, and the changes of cell multiplication and migration were examined by CCK-8 method, EdU test, and scratch-healing test, respectively. Bioinformatics, dual-luciferase reporter gene assay and RIP experiment were adopted to predict and verify the relationship between MCM3AP-AS1 and miR-19a-3p; bioinformatics and dual-luciferase reporter gene assay were adopted to predict and verify the relationship between miR-19a-3p and FOXF2. Western blot was executed to examine the effects of MCM3AP-AS1 overexpression or knockdown on FOXF2 protein expression.

MCM3AP-AS1 expression was down-modulated in CRC, and its dysregulation was linked to unfavorable pathological characteristics. MCM3AP-AS1 significantly impeded the multiplication and migration of CRC cells. MCM3AP-AS1 was recognized as a molecular sponge to suppress miR-19a-3p expression, and FOXF2 was a target gene of miR-19a-3p. MCM3AP-AS1 positively modulated FOXF2 expression, and its biological effect was dependent on miR-19a-3p/FOXF2 axis.

MCM3AP-AS1 can inhibit CRC promoting by modulating the miR-19a-3p/FOXF2 axis.

Long non-coding RNA SNHG8 promotes prostate cancer progression through repressing miR-384 and up-regulating HOXB7.

J Gene Med

Multiple long non-coding RNAs (lncRNAs) have been proved to function as vital regulators in the progression of prostate cancer (PCa). In the present work, we aimed to probe the function of lncRNA small nucleolar RNA host gene 8 (SNHG8) in PCa progression.

qRT-PCR and Western blot were utilized to measure SNHG8, microRNA (miR-384) -384 and homeobox B7 (HOXB7) expressions. CCK-8 and BrdU experiments were employed to evaluate PCa cell proliferation. Transwell experiments were performed to detect PCa cell migration and invasion. Dual-luciferase reporter experiments and RIP experiments were conducted to determine the targeting relationships among miR-384, SNHG8 and HOXB7.

SNHG8 was up-regulated in PCa tissues and cells. Silencing of SNHG8 suppressed proliferation, migration and invasion of PCa cells. SNHG8 functioned as a molecular sponge to repress miR-384. The effects of SNHG8 knockdown on PCa cell proliferation, migration and invasion were counteracted by miR-384 inhibition. HOXB7 was confirmed to be a target gene of miR-384. SNHG8 knockdown repressed HOXB7 expression via targeting miR-384.

SNHG8 promotes PCa cell proliferation, migration and invasion via decoying miR-384 and up-regulating HOXB7.

The brief introduction of meta-analyses in clinical practice and research.

J Gene Med

With the explosive growth of medical information, it is almost impossible for health care providers to review and evaluate all relevant evidence to...

Olfactory coding in honeybees.

Cell and Tissue Research

With less than a million neurons, the western honeybee Apis mellifera is capable of complex olfactory behaviors and provides an ideal model for inv...