The latest medical research on Mircobiology

The research magnet gathers the latest research from around the web, based on your specialty area. Below you will find a sample of some of the most recent articles from reputable medical journals about mircobiology gathered by our medical AI research bot.

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VG161 activates systemic anti-tumor immunity in pancreatic cancer models as a novel oncolytic herpesvirus expressing multiple immunomodulatory transgenes.

Journal of Medical Genetics

The VG161 represents the first recombinant oncolytic herpes simplex virus type 1 carrying multiple synergistic anti-tumor immuno-modulating factors...

Are bladder washing samples suitable for investigation of HPV infection in urinary bladder? Comparison in HPV prevalence between urine and washing samples.

Journal of Medical Genetics

Although urine and bladder washing samples are commonly used for the cytological evaluation of the bladder mucosa, it has been unknown whether these samples are likely suitable to investigate human papillomavirus (HPV) prevalence in the urinary bladder. The present study aimed to elucidate the appropriateness of spontaneously voided urine or bladder washing in screening HPV infection in the urinary bladder.

Urine and bladder washing samples were obtained from 201 patients who underwent transurethral bladder tumor resection. After extracting DNA from both samples, HPV-DNA was examined using a nested polymerase chain reaction with GP5+/6+ and MY09/11 primers. HPV genotyping was performed in the HPV-positive samples. In situ hybridization (ISH) was performed to observe the HPV-DNA localization in urothelial cells among cytological samples and paraffin-embedded tumor tissues in HPV-positive washing samples.

HPV prevalence in urine and washing samples were 9.5% and 7.0%, respectively. High-risk HPV prevalence in urine and washing samples was 7.5% and 4.0%, respectively. The most common HPV type was HPV16, followed by HPV52 and HPV18 in both samples. HPV type distribution in both samples was not in agreement (κ = -0.431). The ISH analysis revealed that HPV-DNA signal was observed in urothelial cells of 5 (55.7%) of 9 detectable HPV-positive cytological samples. Six (66.7%) of 9 HPV-positive cases had HPV-DNA signals in tumor tissue.

The use of washing samples was likely applicable for investigating HPV prevalence in the urinary bladder. HPV-DNA detected in washing samples might be frequently derived from the urinary bladder. This article is protected by copyright. All rights reserved.

Virome analysis provides new insights into the association between viruses and Parkinson's disease.

Journal of Medical Genetics

Parkinson's disease (PD) is a kind of neurodegenerative disease that causes a huge burden to society. Previous studies have suggested the associati...

Route of monkeypox viral inoculum as a determinant of atypical clinical presentation.

Journal of Medical Genetics

our speculation is that the unusual prominent involvement of the anogenital region combined with an atypical or even absent invasive phase could di...

A Significant Predictor of In-Hospital and Long-term Mortality and Progression In COVID-19 Patients: The End-Stage Liver Disease (MELD) Score Model.

Journal of Medical Genetics

The aim of this study is to investigate the relationship between MELD score and disease progression and mortality in COVID-19 patients.

The files of 4213 patients over the age of 18 who were hospitalized with the diagnosis of COVID-19 between 20.03.2020 and 01.05.2021 were retrospectively scanned. Sociodemographic characteristics, chronic diseases, hemogram and biochemical parameters at the time they were diagnosed with COVID-19 of the patients, duration of hospitalization, duration of intensive care unit (ICU), duration of intubation, in-hospital mortality from COVID-19 and outside-hospital mortality for another reason (within the last 1 year) and recurrent hospitalization (within the last 1 year) were recorded. The MELD scores of the patients were calculated. Two groups were formed as MELD score<10 and MELD score≥ 10.

The rate of ICU, in-hospital mortality from COVID-19 and outside-hospital mortality from other causes, intubation rate, recurrent hospitalization were significantly higher in the MELD≥10 group. The duration of ICU, hospitalization, intubation were significantly higher in the MELD≥10 group (p<0.001). As a result of Univariate and Multivariate analysis, MELD score was found to be the independent predictors of ICU, in-hospital mortality, intubation and recurrent hospitalization (p<0.001). MELD score 18.5 predicted ICU with 99% sensitivity and 100% specificity (AUC:0.740, 95%CI 0.717-0.763, p<0.001) also MELD score 18.5 predicted in-hospitale mortality with 99% sensitivity and 100% specificity (AUC:0.797, 95%CI 0.775-0.818, p<0.001).

The MELD score was found to be the independent predictors of in-hospital mortality, ICU admission and intubation in COVID-19 patients. This article is protected by copyright. All rights reserved.

Association of viral load with TRAIL, IP-10, CRP biomarker signature and disease severity in children with respiratory tract infection or fever without source: a prospective, multicentre cohort study.

Journal of Medical Genetics

To investigate the association of viral load (VL) with (i) tumor necrosis factor-related apoptosis inducing ligand (TRAIL), interferon-gamma induced protein-10, C-reactive protein and a combinatorial score (BV score); and (ii) clinical severity.

In this prospective, multicentre cohort sub-study, children with respiratory tract infection or fever without source were enrolled. VL for influenza virus, rhinovirus, respiratory syncytial virus, and adenovirus were measured from nasopharyngeal swabs. The reference standard diagnosis was established based on expert panel adjudication.

Of 1140 recruited patients, 333 had a virus mono-detection. VL for the aggregated dataset correlated with TRAIL and IP-10 levels, with length of oxygen therapy, and inversely with the BV score. On single viral level, only influenza virus yielded a correlation with TRAIL, IP-10 levels, and the BV score. Children with a viral reference standard diagnosis had significantly higher VL than those with bacterial infection (p = 0.0005). Low TRAIL (incidence rate ratio, IRR 0.6, 95% confidence interval, CI 0.39-0.91) and young age (IRR 0.62, 95%CI 0.49-0.79) were associated with longer hospital stay, while young age (IRR 0.33, 95%CI 0.18-0.61), low TRAIL (IRR 0.25, 95%CI 0.08-0.76), and high VL (IRR 1.16, 95%CI 1.00-1.33) were predictive of longer oxygen therapy.

These findings indicate that VL correlates with biomarkers and may serve as a complementary tool pertaining to disease severity. This article is protected by copyright. All rights reserved.

Novel Antibacterial Activity of Febuxostat, an FDA-Approved Antigout Drug against Mycobacterium tuberculosis Infection.

Antimicrobial Agents and Chemotherapy

Accumulating evidence suggests that drug repurposing has drawn attention as an anticipative strategy for controlling tuberculosis (TB), considering...

Genetic predisposition to blood cell indices in relation to severe COVID-19.

Journal of Medical Genetics

Despite of considerable variation in disease manifestations observed among coronavirus disease 2019 (COVID-19) patients infected with severe acute ...

Stability and transmissibility of SARS-CoV-2 in the environment.

Journal of Medical Genetics

SARS-CoV-2, the virus causing the ongoing global COVID-19 pandemic, is believed to be transmitted primarily through respiratory droplets and aeroso...

Broadly neutralizing antibodies recognizing different antigenic epitopes act synergistically against the influenza B virus.

Journal of Medical Genetics

The discovery of broadly neutralizing monoclonal antibodies against influenza viruses has raised hope for the successful development of new antivir...

Efficacy of Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine for the Treatment of Uncomplicated Plasmodium falciparum Malaria among Children in Western Kenya, 2016 to 2017.

Antimicrobial Agents and Chemotherapy

Antimalarial resistance threatens global malaria control efforts. The World Health Organization (WHO) recommends routine antimalarial efficacy moni...

Coinfections in hospitalized patients with severe fever with thrombocytopenia syndrome: a retrospective study.

Journal of Medical Genetics

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease with a high case fatality rate. Few studies have been performed on bacterial or fungal coinfections or the effect of antibiotics therapy.

A retrospective, observational study was performed to assess the prevalence of bacterial and fungal coinfections in patients hospitalized for SFTSV infection. The most commonly involved microorganisms and the effect of antimicrobial therapy were determined by the site and source of infection.

A total of 1201 patients hospitalized with SFTSV infection were included; 359 (29.9%) had microbiologically confirmed infections, comprised of 292 with community-acquired infections (CAIs) and 67 with healthcare-associated infections (HAIs). Death was independently associated with HAIs, with a more significant effect than that observed for CAIs. For bacterial infections, only those acquired in hospital were associated with fatal outcomes, while fungal infection, whether acquired in hospital or community, was related to an increased risk of fatal outcomes. The infections in respiratory tract and bloodstream were associated with a higher risk of death than that in urinary tract. Both antibiotic and antifungal treatments were associated with improved survival for CAIs, while for HAIs, only antibiotic therapy was related to improved survival, and no effect from antifungal therapy was observed. Early administration of glucocorticoids was associated with an increased risk of HAIs.

The study provided novel clinical and epidemiological data and revealed risk factors, such as bacterial coinfections, fungal coinfections, infection sources, and treatment strategies associated with SFTS deaths/survival. This report might be helpful in curing SFTS and reducing fatal SFTS. This article is protected by copyright. All rights reserved.