The latest medical research on Gastroenterology

The research magnet gathers the latest research from around the web, based on your specialty area. Below you will find a sample of some of the most recent articles from reputable medical journals about gastroenterology gathered by our medical AI research bot.

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Insights into the origin of intrahepatic cholangiocarcinoma from mouse models.

Hepatology

Cholangiocarcinoma is a malignant cancer of the bile ducts that can be anatomically classified as intrahepatic (ICC), perihilar (PCC), or extrahepa...

CRLS1 ameliorates nonalcoholic steatohepatitis through ATF3 transcriptional inactivation.

Hepatology

Nonalcoholic steatohepatitis (NASH) is an increasingly prevalent disease that is the major cause of liver dysfunction. Previous research has indica...

Haemostatic alterations in cirrhotic patients: from primary haemostasis to fibrinolysis.

Hepatology

In the setting of liver cirrhosis, profound haemostatic changes occur, which affect primary haemostasis, coagulation, and fibrinolysis. They involv...

Aging-related liver degeneration is associated with increased bacterial endotoxin and lipopolysaccharide binding protein levels.

Am J Physiol

Aging is a risk factor in the development of many diseases including liver-related diseases. The two aims of the present study were (1) to determin...

Severe Neonatal Anemia Increases Intestinal Permeability by Disrupting Epithelial Adherens Junctions.

Am J Physiol

Anemia is a frequent diagnosis in critically-ill infants, but the clinical implications of severe anemia in these patients remain unclear. In this study, we examined pre-weaned mice to investigate the effects of severe anemia during early infancy on gut mucosal permeability.

C57BL/6 mice were subjected to timed phlebotomy between postnatal days (P) 2-10 to induce severe anemia (hematocrits 20-24%), and intestinal permeability was tracked longitudinally between P10-20 as intestine-to-plasma translocation of enteral macromolecules and bacterial translocation. Epithelial junctions were evaluated by electron microscopy, polymerase chain reactions, immunohistochemistry, and/or enzyme immunoassays on intestinal tissues, Caco-2 intestinal epithelial-like cells, and colonic organoids.

Pre-weaned mouse pups showed an age-related susceptibility to severe anemia with increased intestinal permeability to enteral macromolecules (dextran, ovalbumin, β-lactoglobulin) and luminal bacteria. Electron micrographs showed increased paracellular permeability and ultrastructural abnormalities of the adherens junctions. These findings were explained by the loss of E-cadherin in epithelial cells, which was caused by destabilization of the Cdh1 mRNA due to microRNA let-7e-5p binding to the 3'-untranslated region.

Severe anemia resulted in a disproportionate and persistent increase in intestinal permeability in pre-weaned mice due to the disruption of epithelial adherens junctions. These changes are mediated via microRNA let-7e-mediated depletion of Cdh1 mRNA.

Gut microbiota-derived metabolites as key actors in inflammatory bowel disease.

Nat Rev Gastroenterol

A key role of the gut microbiota in the establishment and maintenance of health, as well as in the pathogenesis of disease, has been identified ove...

Early-onset colorectal cancer: initial clues and current views.

Nat Rev Gastroenterol

Over the past several decades, the incidence of early-onset colorectal cancer (EOCRC; in patients <50 years old) has increased at an alarming rate....

Elevated fructose and uric acid via aldose reductase contribute to experimental and human alcoholic liver disease.

Hepatology

Alcohol-associated liver disease (ALD) is a common chronic liver disease worldwide with high morbidity and mortality, and no FDA-approved therapies...

Long-Term Outcomes After Transcatheter and Surgical Aortic Valve Replacement in Patients With Cirrhosis: A Guide for the Hepatologist.

Hepatology

Hepatologists often determine whether transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR) is preferred for pa...

Reciprocal Regulation Between Forkhead Box M1/NF-kB and Methionine Adenosyltransferase 1A Drives Liver Cancer.

Hepatology

Forkhead box M1 (FOXM1) and NF-ĸB are oncogenic drivers in liver cancer that positively regulate each other. We showed that methionine adenosyltran...

Glutamate signaling in alcoholic fatty liver: « PAS DE DEUX ».

Hepatology

Alcoholic liver disease (ALD) is characterized by histological hallmarks including steatosis, inflammation and fibrosis that result from complex in...

Inflammation-induced LINC00665 increases the malignancy through activating PKR/NF-κB pathway in hepatocellular carcinoma.

Hepatology

NF-κB signaling pathway is important for linking inflammation and tumorigenesis. Here, we characterized a NF-κB-signaling-activation induced long i...