The latest medical research on Gastroenterology

The research magnet gathers the latest research from around the web, based on your specialty area. Below you will find a sample of some of the most recent articles from reputable medical journals about gastroenterology gathered by our medical AI research bot.

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Depletion of TRRAP induces p53-independent senescence in liver cancer by downregulating mitotic genes.

Hepatology

Hepatocellular carcinoma (HCC) is an aggressive subtype of liver cancer with few effective treatments and the underlying mechanisms that drive HCC ...

Celiac disease: Should we care about microbes?

Am J Physiol

The prevalence of celiac disease has increased in the last decades suggesting a role for environmental factors in addition to gluten. Several cohor...

Interpretation and implementation of the revised European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) guidelines on pediatric celiac disease amongst consultant general pediatricians in Southwest of England.

Indian Journal of Gastroenterology

Celiac disease (CD) is a lifelong condition with significant morbidity and requires an accurate diagnosis. Guidelines for pediatric CD were revised by the European and British Societies of Paediatric Gastroenterology Hepatology and Nutrition in 2012 and 2013, respectively. New recommendations introduced non-biopsy pathway (NBP) of diagnosis for a selective group of symptomatic children whose anti-tissue transglutaminase (anti-tTG) antibody titer is greater than ten times upper limit of normal. A clear understanding of the guidelines amongst consultant pediatricians will ensure all children with suspected CD receive a prompt and secure diagnosis. The aim of this study was to establish the interpretation and implementation of the revised guideline for CD amongst consultant general pediatricians in Southwest England (SWE) during the study period.

Telephone/email survey was conducted amongst consultant general pediatricians (n ≈ 140) working in 12 secondary care hospitals across SWE. The survey included eight questions incorporating three main themes: understanding of diagnostic pathway particularly for non-biopsy diagnosis, awareness of laboratory tests involved, and variations in practice in relation to the revised guidelines.

Responses were available from 101/140 (72%). One hundred respondents were aware of the revised guidelines for diagnosing CD. However, only 17 respondents stated all the criteria of the guideline required for diagnosis by NBP, with further 17 seeking immediate advice from a specialist. Forty-four listed both the criteria for HLA-DQ2/DQ8 testing applicable to pediatricians. Forty-nine out of 100 pediatricians would commence gluten-free diet only after all the results were available. Thirty-three pediatricians also considered asymptomatic children with high anti-tTG titer eligible for diagnosis of CD by NBP.

There is a need for improved understanding of revised CD guidelines amongst consultant general pediatricians especially while using the NBP and requesting HLA-DQ2/DQ8 testing.

Pathobiology of inherited biliary diseases: a roadmap to understand acquired liver diseases.

Nat Rev Gastroenterol

Bile duct epithelial cells, also known as cholangiocytes, regulate the composition of bile and its flow. Acquired, congenital and genetic dysfuncti...

Slow wave coupling across a gastroduodenal anastomosis as a mechanism for post-surgical gastric dysfunction: evidence for a 'Gastric Aberrant Pathway'.

Am J Physiol

Post-surgical gastric dysfunction is common, but the mechanisms are varied and poorly understood. The pylorus normally acts as an electrical barrie...

Of Potions, Poisons, Polygonum and Pre-emptive Polymorphism.

Hepatology

There are scores of references to plants and herbs in William Shakespeare's plays; he was obviously very knowledgeable about their perceived effect...

High Risk of Fatty Liver Disease Amplifies the Alanine Transaminase-Lowering effect of a HSD17B13 Variant.

Hepatology

A common loss-of-function variant in HSD17B13 (rs72613567:TA) was recently found to protect from chronic liver disease. Whether the variant confers...

Selective Trafficking of Fatty Acids in the Liver: Add Them2 to the List of Influencers.

Hepatology

Non alcoholic fatty liver disease (NAFLD) occurs in 25-40% of the US and European populations, with rates up to 70% in individuals with diabetes me...

Liver transplantation for Acute Liver Failure due to Dengue fever: first successful reported case worldwide.

Hepatology

Dengue fever (DF) is the most common viral hemorrhagic fever worldwide, mainly transmitted through mosquito bites in tropical and sub-tropical coun...

Childhood socioeconomic disadvantage and risk of fatty liver in adulthood: the Cardiovascular Risk in Young Finns Study.

Hepatology

Fatty liver is a preventable cause of liver failure, but early risk factors for adulthood fatty liver are poorly understood. We examined the associ...

Tumor-specific Transcripts are Frequently Expressed in Hepatocellular Carcinoma with Clinical Implication and Potential Function.

Hepatology

Hepatocellular carcinoma (HCC) is a highly lethal cancer and its underlying etiology remains understudied. The immense diversity and complexity of ...

Ablation of hepatocyte Smad1, Smad5 and Smad8 causes severe tissue iron loading and liver fibrosis in mice.

Hepatology

A failure of iron to appropriately regulate liver hepcidin production is central to the pathogenesis of hereditary hemochromatosis. SMAD1/5 transcr...