The latest medical research on Gastroenterology

The research magnet gathers the latest research from around the web, based on your specialty area. Below you will find a sample of some of the most recent articles from reputable medical journals about gastroenterology gathered by our medical AI research bot.

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Surgical method for establishing posthepatectomy liver failure.

Hepatology

We read with great interest the article by Chen et al. entitled "Randomized Trial of Spheroid Reservoir Bioartificial Liver in Porcine Model of Pos...

Spontaneous Regression of HCC- When the Immune System Stands Up to Cancer.

Hepatology

Spontaneous regression of cancer is rare and has been observed mostly in immunogenic cancers like melanoma. A few cases of spontaneous regression o...

The Power of Single Cell Analysis for the Study of Liver Pathobiology.

Hepatology

Single cell transcriptomics has emerged as a powerful lens through which to study the molecular diversity of complex tissues such as the liver, dur...

TET1 promotes malignant progression of cholangiocarcinoma with IDH1 wild-type.

Hepatology

Cholangiocarcinoma (CCA) is a highly lethal disease without effective therapeutic approaches. The whole genome sequencing data indicated that there...

Parkinson disease and the gut: new insights into pathogenesis and clinical relevance.

Nat Rev Gastroenterol

The classic view portrays Parkinson disease (PD) as a motor disorder resulting from loss of substantia nigra pars compacta dopaminergic neurons. Mu...

Multiple roles for hepatitis B and C viruses and the host in the development of hepatocellular carcinoma.

Hepatology

Chronic hepatitis B and C are major risk factors for hepatocellular carcinoma (HCC) in the United States and worldwide. Direct and indirect mechani...

The Functional Role of the Secretin/Secretin Receptor Signaling During Cholestatic Liver Injury.

Hepatology

The gastrointestinal peptide, secretin (Sct) is an important homeostatic regulator of pancreatic and liver secretory function. With regard to the l...

Prenatal Exposure to Perfluoroalkyl Substances Associated with Increased Susceptibility to Liver Injury in Children.

Hepatology

Per- and polyfluoroalkyl substances (PFAS) are widespread and persistent pollutants that have been shown to have hepatotoxic effects in animal models. However, human evidence is scarce. We evaluated how prenatal exposure to PFAS associates with established serum biomarkers of liver injury and alterations in serum metabolome in children.

We used data from 1105 mothers and their children (median age 8.2 years, IQR 6.6-9.1) from the European Human Early-Life Exposome (HELIX) cohort (consisting of six existing population-based birth cohorts in France, Greece, Lithuania, Norway, Spain, and the UK). We measured concentrations of perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), perfluorononanoate (PFNA), perfluorohexane sulfonate (PFHxS), and perfluoroundecanoate (PFUnDA) in maternal blood. We assessed concentrations of alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyltransferase in child serum. Using Bayesian Kernel Machine regression, we found that higher exposure to PFAS during pregnancy was associated with higher liver enzyme levels in children. We also measured child serum metabolomics through a targeted assay and found significant perturbations in amino acid and glycerophospholipid metabolism associated with prenatal PFAS. A latent variable analysis identified a profile of children at high risk of liver injury (OR 1.56, 95% CI 1.21-1.92) that was characterized by high prenatal exposure to PFAS and increased serum levels of branched-chain amino acids (valine, leucine, isoleucine), aromatic amino acids (tryptophan and phenylalanine), and glycerophospholipids (phosphatidylcholine PC aa C36:1 and Lyso-PC a C18:1).

Developmental exposure to PFAS can contribute to pediatric liver injury.

The stimulus intensity-dependent recruitment of NaV1 subunits in action potential initiation in nerve terminals of vagal C-fibers innervating the esophagus.

Am J Physiol

We investigated voltage-gated sodium channels (NaV1) subunits that regulate action potential initiation in the nerve terminals of vagal nodose C-fi...

A murine model of pediatric inflammatory bowel disease causes microbiota-gut-brain axis deficits in adulthood.

Am J Physiol

Inflammatory bowel diseases (IBDs) are chronic intestinal diseases, frequently associated with comorbid psychological and cognitive deficits. These...

Intestinal epithelial glycosylation in homeostasis and gut microbiota interactions in IBD.

Nat Rev Gastroenterol

Inflammatory bowel disease (IBD) affects 6.8 million people globally. A variety of factors have been implicated in IBD pathogenesis, including host...

Improving the Efficacy of Liver Cancer Immunotherapy: the Power of Combined Preclinical and Clinical Studies.

Hepatology

Hepatocellular carcinoma (HCC) is a most deadly malignant disease worldwide, with no effective mechanism-based therapy available. Therefore, follow...