The latest medical research on Clinical Pharmacology
The research magnet gathers the latest research from around the web, based on your specialty area. Below you will find a sample of some of the most recent articles from reputable medical journals about clinical pharmacology gathered by our medical AI research bot.
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Predictors of Cisatracurium Continuous Infusion Dose in Acute Respiratory Distress Syndrome.Journal of Pharmacy and Pharmacology
Neuromuscular blockade (NMB) with cisatracurium may improve outcomes in the acute respiratory distress syndrome (ARDS) population; however, optimal...
Distinct acute effects of LSD, MDMA, and D-amphetamine in healthy subjects.Neuropsychopharmacology
Lysergic acid diethylamide (LSD) is a classic psychedelic, 3,4-methylenedioxymethamphetamine (MDMA) is an empathogen, and D-amphetamine is a classi...
Assessment of the Impact of Clinical Pharmacology Consultations Provided to Hospital Clinicians From the Drug Information Center-An Outcome Research in a Developing Country.Journal of Pharmacy and Pharmacology
Drug Information Center (DIC) with on-call evidence-based medicine service can revolutionize health-care practice and also can play a major role in health-care delivery in both developed and developing countries.
To assess the feedback received from hospital clinicians for the newly initiated DIC services in a tertiary care hospital of North India.
This is a retrospective cohort study conducted between January 1, 2016, to December 31, 2018. The clinicians approached DIC for specific pharmacotherapeutic questions for managing an index patient. After providing consultation, DIC followed up with them for the action taken and feedback on the consultation. The results of the data analyzed using Fisher Exact test and descriptive statistics.
Of 264 encounters, more than 98% of clinicians found the service satisfactory. There was a statistically significant association between the timely answer provided to treating physicians and their level of satisfaction with the service (P < .05). There was no significant association between academic experiences and the satisfaction or dissatisfaction among the clinical fraternity colleagues. The interpretation ability of on-call pharmacology postgraduate students was a significantly associated factor with clinician's satisfaction level (P < .05). More than 96% of clinicians followed the pharmacotherapy advice recommended by DIC in their patient management.
Thorough evaluation of published research needs to be taught to budding pharmacologists, pharmacists in their curriculum for an effective DIC service. DIC service has the potential to minimize the barrier of evidence-based medicine practice in developing as well as developed countries.
Clinical Pharmacist's Role in an Alcohol Detox Unit in a Correctional Setting.Journal of Pharmacy and Pharmacology
Newly incarcerated inmates with chronic alcohol use are at high risk for alcohol withdrawal. This descriptive study aims to describe the role of a clinical pharmacist within an alcohol detoxification unit (ADU) in the Los Angeles County jail that serves nearly 18 000 inmates facility-wide daily.
This descriptive analysis was conducted from August 2, 2018 through October 31, 2018 within the jail ADU. The pharmacist attended daily assessments on all alcohol detox patients; identified and assessed patients at high risk of severe withdrawal; and initiated, modified, and discontinued withdrawal medication for selected patients. Patients were determined to be high risk of severe withdrawal if they had history of severe withdrawal, any Clinical Institute Withdrawal Assessment for Alcohol-revised (CIWA-Ar) score ≥15, or polysubstance withdrawal.
A total of 1263 patients were admitted to the ADU during the study (average 97 per week). A total of 282 patients were assessed by the pharmacist. Patient assessments included substance use and medication history, CIWA-Ar score, response to pharmacotherapy, and referral to a substance use counselor. Medications were initiated, modified, or discontinued in 148 patients after discussion with a physician. Transfer to an acute care facility occurred in 48 patients. Zero alcohol detox patient deaths occurred during the study.
This is a novel role of a pharmacist in a correctional setting. A pharmacist can aid in an ADU by identifying and assessing patients at high risk of severe withdrawal and managing pharmacotherapy. Future studies can examine pharmacist withdrawal management of additional substances.
A survey of antibiotic administration practices involving patients with sepsis in UK critical care units.International Journal of Epidemiology
Background Alternative administration methods are emerging as a key area of research to improve clinical efficacy of antibiotics and address concer...
Interdisciplinary medication review to improve pharmacotherapy for patients with intellectual disabilities.International Journal of Epidemiology
Background Patients with intellectual disabilities is an underserved patient group that have poor abilities to express their health complaints. Obj...
Implementation of clinical pharmacist recommendations and services at a University Hospital in Yemen.International Journal of Epidemiology
Background Studies have revealed that the inclusion of a clinical pharmacist as a member in multidisciplinary medical team has been associated with...
Tigecycline-induced coagulopathy: a literature review.International Journal of Epidemiology
Background Several adverse reactions to tigecycline, which is widely used in patients with severe infections, have been documented. Coagulopathy is...
Benefits, risks and impacts on quality of life of medications used in multimorbid older adults: a Delphi study.International Journal of Epidemiology
Background Multimorbidity and polypharmacy are common in older people. Despite the existence of quality criteria for medication use among this popu...
Beliefs about medicines in pregnancy: a survey using the beliefs about medicines questionnaire in Indonesia.International Journal of Epidemiology
Background Many studies examine the use of medicines among pregnant women, however few studies report the pregnant women's belief for taking medica...
The effect of chronic oxytocin treatment during abstinence from methamphetamine self-administration on incubation of craving, reinstatement, and anxiety.Neuropsychopharmacology
Methamphetamine (METH) abuse is characterised by chronic relapse and anxiety, for which there are no effective pharmacotherapies. Acute treatment w...
Systematic review and narrative synthesis of pharmacist provided medicines optimisation services in care homes for older people to inform the development of a generic training or accreditation process.International Journal of Epidemiology
To develop a training programme to enable pharmacists with prescribing rights to assume responsibility for the provision of pharmaceutical care within care homes, a systematic review and narrative synthesis was undertaken to identify reported approaches to training pharmacists and use this literature to identify potential knowledge requirements.
A PROSPERO-registered systematic review was performed using key search terms for care homes, pharmacist, education, training and pharmaceutical care. Papers reporting primary research focussed on care of the older person within the care home setting were included. No restrictions were placed on methodology. Two researchers independently reviewed titles, abstracts and papers. Agreement on inclusion was reached through consensus. Data on titles, training and activities undertaken were extracted and knowledge requirements identified. Findings were synthesised and reported narratively.
Fifty-nine papers were included, most of which were uncontrolled service evaluations. Four papers reported an accreditation process for the pharmacist. Thirteen papers reported providing tools or specific training on a single topic to pharmacists. The main clinical and therapeutic areas of activity (requiring codified knowledge) were dementia, pain, antipsychotic and cardiovascular medication. Provision of pharmaceutical care, effective multidisciplinary working and care home staff training represented the main areas of practical knowledge.
Information regarding training and accreditation processes for care home pharmacists is limited. This study provides insight into potential codified and practical knowledge requirements for pharmacists assuming responsibility for the provision of pharmaceutical care within care homes. Further work involving stakeholders is required to identify the cultural knowledge requirements and to develop a training and accreditation process.