The latest medical research on Liver Cancer
The research magnet gathers the latest research from around the web, based on your specialty area. Below you will find a sample of some of the most recent articles from reputable medical journals about liver cancer gathered by our medical AI research bot.
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Request AccessTreatment of Mental Health in Patients With Chronic Liver Disease.
Clinical Liver DiseaseContent available: Author Interview and Audio Recording.
Behavioral health disorders related to nonalcoholic steatohepatitis.
Clinical Liver DiseaseContent available: Author Interview and Audio Recording.
Psychiatric Disorders and Their Treatment: Impact of Outcomes in Patients With Chronic Liver Disease.
Clinical Liver DiseaseContent available: Audio Recording.
Sociodemographic Risk Factors for Depression in Patients With Chronic Liver Disease.
Clinical Liver DiseaseContent available: Audio Recording.
Assessment of mental health in patients with chronic liver disease.
Clinical Liver DiseaseContent available: Audio Recording.
Assessment of Alcohol and Other Substance Use in Patients With Chronic Liver Disease.
Clinical Liver DiseaseContent available: Audio Recording.
Treatments for obesity in the context of nonalcoholic steatohepatitis and mental health.
Clinical Liver DiseaseContent available: Audio Recording.
Natural history, spectrum and outcome of stage 3 AKI in patients with acute-on-chronic liver failure.
Liver InternationalThere is limited data on natural course and interventions in stage-3 acute kidney injury (AKI-3) in patients with acute-on-chronic liver failure (ACLF). We studied the factors of AKI-3 reversal and outcomes on dialysis in ACLF patients.
Consecutive patients with ACLF were prospectively enrolled (n=1022) and variables determining AKI and its outcomes were analyzed.
At one-month, 337(33%) patients had AKI-3, of which, 131 had AKI-3 at enrolment, 206 developed AKI-3 during hospital stay. Of patients with AKI-3 at enrolment, 18% showed terlipressin response, 21% had AKI resolution and 59% required dialysis. High MELD (≥35) (model 1), serum bilirubin (≥ 23 mg/dl) (model 2) and AARC score (≥11) (model 3) were independent risk factors for dialysis. Dialysis was associated with worse survival in all AKI patients but improved outcomes in patients with AKI-3 [p=0.022, HR 0.69(0.50-0.95). Post-mortem kidney biopsies (n= 61) revealed cholemic nephropathy (CN) in 54%, acute tubular necrosis (ATN) in 31%, and a combination (CN and ATN) in 15%. Serum bilirubin was significantly higher in patients with CN, CN and ATN compared with ATN respectively [(30.8 ± 12.2) vs. (26.7 ± 12.0) vs. (18.5 ± 9.8); p=0.002].
AKI-3 rapidly increases from 13% to 33% within 30 days in ACLF patients. Histopathological data suggested cholemic nephropathy as the predominant cause which correlated with high bilirubin levels. AKI-3 resolves in only one in five patients. Patients with AARC grade 3 and MELD >35 demand need for early dialysis in AKI-3 for improved outcomes.
Interferon-based treatment of chronic hepatitis D.
Liver InternationalTreatment of hepatitis D virus (HDV) infection has been based on the administration of interferon-alfa for more than three decades. First studies t...
DLK1-directed chimeric antigen receptor T-cell therapy for hepatocellular carcinoma.
Liver InternationalDelta-like homolog 1 (DLK1), a transmembrane protein, is highly expressed in hepatocellular carcinoma (HCC). We explored whether DLK1-directed chimeric antigen receptor (CAR) T cells can specifically eliminate DLK1-positive HCC cells and serve as a therapeutic strategy for HCC immunotherapy.
We first characterized a homemade anti-human DLK1 monoclonal antibody, sequenced the single-chain Fragment variable (scFv) and integrated it into the second-generation CAR lentiviral vector, and then developed the DLK1-directed CAR-T cells. The cytotoxic activities of DLK1-directed CAR-T cells against different HCC cells were evaluated in vitro and in vivo.
The genetically modified human T cells with the DLK1-directed CARs produced cytotoxic activity against DLK1-positive HCC cells. Additionally, the DLK1-directed CARs enhanced T cell proliferation and activation in a DLK1-dependent manner. Interestingly, the DLK1-targeted CAR-T cells significantly inhibited both subcutaneous and peritoneal xenograft tumors derived from human liver cancer cell lines HepG2 or Huh-7.
DLK1-directed CAR T cells specifically suppresses DLK1-positive HCC cells in vitro and in vivo. This study provides a novel transmembrane antigen DLK1 as a potential therapeutic target appropriate for CAR-T cell therapy, which may be further developed as a clinical therapeutic strategy for HCC immunotherapy.
Real-life experiences with bulevirtide for the treatment of hepatitis delta - forty-eight weeks data from a German center.
Liver InternationalIn July 2020, the entry inhibitor bulevirtide was approved in the European Union for the treatment of chronic hepatitis delta virus (HDV) infection...
Acyl-CoA thioesterase 9 promotes tumor growth and metastasis through reprogramming of fatty acid metabolism in hepatocellular carcinoma.
Liver InternationalAcyl-CoA thioesterase 9 (ACOT9) is a critical regulator of cellular utilization of fatty acids by catalyzing the hydrolysis of acyl-CoA thioesters ...
