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The latest medical research on Neuroendocrine Tumors

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Prognostic of recurrence and survival in poorly differentiated thyroid cancer.

Neuroendocrine Tumors

The prognosis of poorly differentiated thyroid carcinomas (PDTC) defined by the Turin criteria is variable. The aim of this study on 51 PDTC patien...

DNA methylation is a comprehensive marker for pediatric adrenocortical tumors.

Neuroendocrine Tumors

Children diagnosed with adrenocortical tumors (pACT) have variable outcomes and, to date, the disease lacks robust prognostic biomarkers. The progn...

Tumor suppressor gene ARMC5 controls adrenal redox state through NRF1 turnover.

Neuroendocrine Tumors

ARMC5 is a tumor suppressor gene frequently mutated in primary bilateral macronodular adrenal hyperplasia (PBMAH), an adrenal cause of Cushing's sy...

Molecular mechanisms of resistance to kinase inhibitors in thyroid cancers.

Neuroendocrine Tumors

Protein kinases play critical roles in cell survival, proliferation and motility. Their dysregulation is therefore a common feature in the pathogen...

The immune cell infiltrate in the tumour microenvironment of phaeochromocytomas and paragangliomas.

Neuroendocrine Tumors

Emerging evidence suggests the composition of the tumour microenvironment (TME) correlates with clinical outcome and that each tumour type has a un...

Succinate dehydrogenase and MYC-associated factor X mutations in pituitary neuroendocrine tumours.

Neuroendocrine Tumors

Pituitary neuroendocrine tumours (PitNETs) associated with paragangliomas or phaeochromocytomas are rare. SDHx variants are estimated to be associa...

Precocious puberty due to intracranial germ cell tumors: a case-control study.

Neuroendocrine Tumors

Children with intracranial germ cell tumors may present premature sexual development via either GnRH-dependent cause or GnRH-independent cause. We ...

Paediatric differentiated thyroid carcinoma: a UK National Clinical Practice Consensus Guideline.

Neuroendocrine Tumors

This guideline is written as a reference document for clinicians presented with the challenge of managing paediatric patients with differentiated t...

Key factors for effective mitotane therapy in children with adrenocortical carcinoma.

Neuroendocrine Tumors

Adjuvant treatment with mitotane and chemotherapy is recommended for paediatric advanced and metastatic adrenocortical carcinoma (ACC). Yet, questi...

Androgen receptor mutations for precision medicine in prostate cancer.

Neuroendocrine Tumors

Hormonal therapies including androgen deprivation therapy and androgen receptor (AR) pathway inhibitors such as abiraterone and enzalutamide have b...

Second-line treatment and prognostic factors in neuroendocrine carcinoma.

Neuroendocrine Tumors

Neuroendocrine carcinomas (NEC) are aggressive malignant diseases. Etoposide-based rechallenge (EBR) and the prognostic role of Rb status in second...

Improved pasireotide response in USP8 mutant corticotroph tumours in vitro.

Neuroendocrine Tumors

Cushing's disease is a rare, but devastating and difficult to manage condition. The somatostatin analogue pasireotide is the only pituitary targeti...