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The latest medical research on Stomach Cancer

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Noninvasive imaging of the tumor immune microenvironment correlates with response to immunotherapy in gastric cancer

Nature's Stomach Cancer

Tumour microenvironment has been linked with immunotherapy response in gastric cancer. Here, the authors use CT-based radiomics to predict neutroph...

Cell death affecting the progression of gastric cancer

Nature's Stomach Cancer

Gastric cancer is a gastrointestinal tumor with high morbidity and mortality rates. Several factors influence its progression, cell death being an ...

Intratumoral PD-1+CD8+ T cells associate poor clinical outcomes and adjuvant chemotherapeutic benefit in gastric cancer

Nature's Stomach Cancer

Although PD-1 has been reported to be a marker of T-cell exhaustion in several malignancies, the biological role of PD-1+CD8+ T cells in gastric ca...

CDK5RAP3 acts as a tumour suppressor in gastric cancer through the infiltration and polarization of tumour-associated macrophages

Nature's Stomach Cancer

We have demonstrated that CDK5RAP3 exerts a tumour suppressor effect in gastric cancer, but its role in regulating tumour-associated macrophages (T...

scRNA-seq of gastric tumor shows complex intercellular interaction with an alternative T cell exhaustion trajectory

Nature's Stomach Cancer

Gastric cancer can vary in tumour stage and immune cell involvement. Here the authors compare gene expression in immune cell types from the blood a...

Development and validation of multivariate models integrating preoperative clinicopathological and radiographic findings to predict HER2 status in gastric cancer

Nature's Stomach Cancer

The combination of trastuzumab and chemotherapy is recommended as first-line therapy for patients with human epidermal growth factor receptor 2 (HE...

Predicting response to immunotherapy in gastric cancer via multi-dimensional analyses of the tumour immune microenvironment

Nature's Stomach Cancer

Predictive methods for gastric cancer to try and differentiate between potential treatment response are required. Here the authors use a multiplexe...

m6A RNA methylation-mediated NDUFA4 promotes cell proliferation and metabolism in gastric cancer

Nature's Stomach Cancer

Gastric cancer (GC) is a malignancy with poor prognosis. NDUFA4 is reported to correlate with the progression of GC. However, its underlying mechan...

Non-enzymatic heparanase enhances gastric tumor proliferation via TFEB-dependent autophagy

Nature's Stomach Cancer

Non-enzymatic HPA reduces mTOR expression and inhibits TFEB phosphorylation, resulting in dissociation of mTOR binding to 14-3-3 protein. The depho...

A novel high-risk subpopulation identified by CTSL and ZBTB7B in gastric cancer

Nature's Stomach Cancer

Gastric cancer (GC) is characterised by a heterogeneous tumour microenvironment (TME) that is closely associated with the response to treatment, es...

Comparison of the gastric microbiome in Billroth I and Roux-en-Y reconstructions after distal gastrectomy

Nature's Stomach Cancer

The changes in gastric microbiota following reconstruction after gastrectomy have not been reported. This study aimed to compare the gastric microb...

ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination

Nature's Stomach Cancer

Ariadne homolog 2 (ARIH2) is a key member of the RING-between-RING (RBR) E3 ligase family, which is characterized by an RBR domain involved in the ...