The latest medical research on Sarcoma

The research magnet gathers the latest research from around the web, based on your specialty area. Below you will find a sample of some of the most recent articles from reputable medical journals about sarcoma gathered by our medical AI research bot.

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Phase transition and remodeling complex assembly are important for SS18-SSX oncogenic activity in synovial sarcomas

Nature's Sarcoma

Oncoprotein SS18-SSX is a hallmark of synovial sarcoma. Here the authors report phase separation of SS18-SSX and the binding of SS18-SSX to chromat...

Targeting the translational machinery in gastrointestinal stromal tumors (GIST): a new therapeutic vulnerability

Nature's Sarcoma

Although KIT-mutant GISTs can be effectively treated with tyrosine kinase inhibitors (TKIs), many patients develop resistance to imatinib mesylate ...

Recurrent YAP1::MAML2 fusions in “nodular necrotizing” variants of myxoinflammatory fibroblastic sarcoma: a comprehensive study of 7 cases

Nature's Sarcoma

Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare soft tissue tumor with a predilection for the distal extremities and a tendency for local re...

Mitochondrial calcium uptake regulates tumour progression in embryonal rhabdomyosarcoma

Nature's Sarcoma

Embryonal rhabdomyosarcoma (ERMS) is characterised by a failure of cells to complete skeletal muscle differentiation. Although ERMS cells are vulne...

Artificial intelligence significantly improves the diagnostic accuracy of deep myxoid soft tissue lesions in histology

Nature's Sarcoma

Deep myxoid soft tissue lesions have posed a diagnostic challenge for pathologists due to significant histological overlap and regional heterogenei...

Hypoxia-activated neuropeptide Y/Y5 receptor/RhoA pathway triggers chromosomal instability and bone metastasis in Ewing sarcoma

Nature's Sarcoma

Ewing sarcoma tumour cells frequently metastasize to the bone but the molecular mechanisms governing this process are not well understood. Here, th...

EWSR1-ATF1 dependent 3D connectivity regulates oncogenic and differentiation programs in Clear Cell Sarcoma

Nature's Sarcoma

The relationship between cellular histogenesis and molecular phenotypes for the EWSR1- ATF1 fusion in clear cell sarcoma (CCS) requires further cha...

Drivers of genomic loss of heterozygosity in leiomyosarcoma are distinct from carcinomas

Nature's Sarcoma

Leiomyosarcoma (LMS) is a rare, aggressive, mesenchymal tumor. Subsets of LMS have been identified to harbor genomic alterations associated with ho...

Targeting farnesylation as a novel therapeutic approach in HRAS-mutant rhabdomyosarcoma

Nature's Sarcoma

Activating RAS mutations are found in a subset of fusion-negative rhabdomyosarcoma (RMS), and therapeutic strategies to directly target RAS in thes...