The latest medical research on Microbiology

The research magnet gathers the latest research from around the web, based on your specialty area. Below you will find a sample of some of the most recent articles from reputable medical journals about microbiology gathered by our medical AI research bot.

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Kir7.1 disease mutant T153I within the inner pore affects K+ conduction.

Cellular Physiology

Inward-rectifier potassium channel 7.1 (Kir7.1) is present in polarized epithelium, including the RPE. A single amino acid change at position 153 i...

The Senescence-Associated Secretory Phenotype in Ovarian Cancer Dissemination.

Cellular Physiology

Ovarian cancer is a highly aggressive disease with poor survival rates in part due to diagnosis after dissemination throughout the peritoneal cavit...

DOCK2 contributes to pulmonary fibrosis by promoting lung fibroblast to myofibroblast transition.

Cellular Physiology

Idiopathic pulmonary fibrosis (IPF) is the most common chronic interstitial lung disease and is characterized by the progressive scarring of the lu...

Indolent T-lymphoblastic proliferation: A systematic review of the literature analyzing the epidemiologic, clinical, and pathologic features of 45 cases.

Biochemistry

An indolent T-lymphoblastic proliferation (iT-LBP) is a rare benign disorder characterized by an abnormal expansion of immature T-cells, which morp...

Bone marrow and peripheral blood involvement of relapsed diffuse large B-cell lymphoma after prior cold agglutinin disease.

Biochemistry

The author report an interesting case of relapsed diffuse large B-cell lymphoma (DLBCL) with bone marrow (BM) and peripheral blood (PB) involvement...

Dopamine Receptor Signaling Regulates Fibrotic Activation of Retinal Pigmented Epithelial Cells.

Cellular Physiology

Retinal pigmented epithelial (RPE) cells play an important role in retinal fibrotic diseases such as proliferative vitreoretinopathy (PVR). The pur...

The glycosaminoglycan interactome 2.0.

Cellular Physiology

Glycosaminoglycans (GAGs) are complex linear polysaccharides, which are covalently attached to core proteins (except for hyaluronan) to form proteo...

Exploiting adaptive immune receptor recombination read recoveries from exome files to identify subsets of ALL and to establish TCR features that correlate with better outcomes.

Biochemistry

The recovery of adaptive immune receptor (IR) recombination reads from tumour-derived genomics files has advanced the understanding of the immune system's interaction with cancer. This approach has been largely limited to solid tumours, where genomics file preparation allows for the recovery of adaptive IR reads corresponding to the T-cells and B-cells found in the solid tumour microenvironment. In this study, we sought to determine whether IR recombination reads from liquid tumour genomics files could also be informative.

We recovered the adaptive IR recombination reads from acute lymphoblastic leukaemia (ALL) normal and pathological genomics files of the Therapeutically Applicable Research to Generate Effective Treatments (TARGET)-ALL, phase 2 project.

In the bone marrow setting, results indicated that there was little or no B-cell response to ALL. However, results did show survival distinctions for B-cell ALL, in cases with specific T-cell complementarity determining region-3 chemical features, potentially reflecting specificity of the adaptive T-cell response against ALL. Furthermore, we found that the B-cell form of ALL, as well as what is likely TRD clonotypic, T-cell ALL, could likely be diagnosed via the recovery of B-cell receptor and TRD recombination reads, respectively, from pathological bone marrow exome files.

Recovery of IR recombination reads from ALL exomes could aid in sub-type diagnoses and prognoses.

Porcine Choroid Plexus-Riems cell line demonstrates altered polarization of transport proteins in comparison to the native epithelium.

Cellular Physiology

The choroid plexus epithelium (CPe) forms a barrier between the cerebral blood supply and the cerebrospinal fluid (CSF), establishing the blood-CSF...

Heat shock proteins in pulmonary fibrosis: pawns of cell homeostasis.

Cellular Physiology

Idiopathic lung fibrosis (IPF) is a fatal disease that primarily affects the elderly. Up to date, the specific pathophysiology of IPF remains unkno...

Bidirectional relationships between the gut microbiome and sexual traits.

Cellular Physiology

The human gut microbiota is known to be shaped by a variety of environmental factors (diet, drugs, geography and sanitation) and host intrinsic fac...

The role of mitochondria in the pathophysiology and treatment of common metabolic diseases in humans.

Cellular Physiology

Common metabolic diseases such as obesity, type 2 diabetes mellitus and non-alcoholic fatty liver disease significantly contribute to morbidity and...